{"id":90,"date":"2024-09-27T11:08:59","date_gmt":"2024-09-27T15:08:59","guid":{"rendered":"https:\/\/ar.bu.edu\/2024\/?page_id=90"},"modified":"2024-11-18T14:22:42","modified_gmt":"2024-11-18T19:22:42","slug":"cte","status":"publish","type":"page","link":"https:\/\/ar.bu.edu\/2024\/gray-matter\/cte\/","title":{"rendered":"Advancing CTE Diagnosis"},"content":{"rendered":"

A new study from BU\u2019s Chronic Traumatic Encephalopathy (CTE) Center<\/a> offers insight into diagnosing CTE while a person is still living. <\/strong><\/p>\n

CTE is commonly found during autopsies on athletes like football and soccer players who endure frequent blows to the head. But how is it connected to a range of cognitive, behavioral, and neurological symptoms\u2014or is it connected at all? The BU study is helping to answer these questions. \u201cFor the first time, we were able to show a clear dose-response relationship between the amount of CTE pathology and the severity of cognitive and functional symptoms, including problems with memory and executive function,\u201d says Jesse Mez<\/strong><\/a>, CTE Center codirector of clinical research, associate professor of neurology, and coauthor of the study.<\/p>\n

The research team measured a protein called p-tau across 10 different brain regions in 364 brains with CTE that were donated to BU\u2019s UNITE Brain Bank<\/strong><\/a>. They asked family and friends of the brain donors for insights on their loved one\u2019s cognitive, functional, mood, and behavioral symptoms.<\/p>\n

\u201cThese findings provide a clear step forward toward diagnosing CTE in life.\u201d<\/p>\n

\u2014JESSE MEZ<\/p><\/blockquote>\n

These symptoms had a direct correlation to the presence of the p-tau protein, the study found. And p-tau in the frontal lobe was associated with some neurobehavioral symptoms\u2014like the reduced ability to control impulses and self-monitor behavior\u2014but overall, there was a higher correlation between cognition than neurobehavior.<\/p>\n

\"\"
Neurologists Michael Alosco <\/strong>and Jesse Mez<\/strong>\u2019s study brings us closer to diagnosing CTE while a patient is still alive.<\/figcaption><\/figure>\n

The team understands the vast importance of these findings, along with the need to create a more robust analysis. \u201cThis can offer valuable information,\u201d says study coauthor Michael Alosco<\/strong><\/a>, CTE Center codirector of clinical research and associate professor of neurology. \u201cBut we need to move toward a model where we objectively assess individuals during life and follow them until brain donation.\u201d<\/p>\n

As the research continues, there is new hope for potential therapies to help CTE patients before it\u2019s too late. \u201cThese findings provide a clear step forward toward diagnosing CTE in life<\/a>,\u201d says Mez.<\/p>\n","protected":false},"excerpt":{"rendered":"

A new study from BU\u2019s Chronic Traumatic Encephalopathy (CTE) Center offers insight into diagnosing CTE […]<\/p>\n","protected":false},"author":1859,"featured_media":0,"parent":86,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"bu-landing","meta":[],"_links":{"self":[{"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/pages\/90"}],"collection":[{"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/users\/1859"}],"replies":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/comments?post=90"}],"version-history":[{"count":10,"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/pages\/90\/revisions"}],"predecessor-version":[{"id":769,"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/pages\/90\/revisions\/769"}],"up":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/pages\/86"}],"wp:attachment":[{"href":"https:\/\/ar.bu.edu\/2024\/wp-json\/wp\/v2\/media?parent=90"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}