{"id":78,"date":"2025-10-31T15:20:02","date_gmt":"2025-10-31T19:20:02","guid":{"rendered":"https:\/\/ar.bu.edu\/2025\/?page_id=78"},"modified":"2025-11-25T17:06:26","modified_gmt":"2025-11-25T22:06:26","slug":"ilet","status":"publish","type":"page","link":"https:\/\/ar.bu.edu\/2025\/scientific-progress\/ilet\/","title":{"rendered":"&#8220;This Device Means Rory Can Live Like Any Other Kid&#8221;"},"content":{"rendered":"<p><em>Above: Rory Mansfield has type 1 diabetes but lives a normal life, says his mother, Betsey Monaco, a pediatrician. Ed Damiano, research professor of biomedical engineering at Boston University, coinvented the iLet Bionic Pancreas, an automated insulin delivery device.<\/em><\/p>\n<p><strong>Rory Mansfield<\/strong> has type 1 diabetes, but these days he can visit a friend\u2019s house, play soccer, and eat what he wants\u2014like any other kid. It\u2019s all thanks to the iLet Bionic Pancreas\u2014developed in a BU lab by engineering professor <a href=\"https:\/\/www.bu.edu\/eng\/profile\/edward-damiano-ph-d\/\"><strong>Ed Damiano<\/strong><\/a>\u2014which automatically delivers just enough insulin to correct the user\u2019s blood sugar.<\/p>\n<p>Rory\u2019s mother, pediatrician <strong>Betsey Monaco<\/strong>, says she and her husband, Paul Mansfield, lost a lot of sleep testing blood sugar levels, giving injections, and just worrying about Rory and his brother Frankie, who is also diabetic. Then, in 2023, Rory got the iLet from Beta Bionics, a company Damiano cofounded.<\/p>\n<p>Monaco talks to Damiano about how the iLet allows Rory to live a more normal life. Damiano began conceptualizing the device in 2000, after his infant son was diagnosed with type 1 diabetes. He began preclinical testing at BU in 2005 and clinical trials, with Dr. Steven Russell, in 2008. Damiano is delighted that, in the short time the device has been commercially available, it has already helped thousands of families like Monaco\u2019s: \u201cThe project has been more rewarding than I ever imagined.\u201d<\/p>\n<hr \/>\n<div class=\"video-collapsible\"><div class=\"bu_collapsible_container \" aria-live=\"polite\" data-customize-animation=\"false\"><h2 class=\"bu_collapsible\" aria-expanded=\"false\"tabindex=\"0\" role=\"button\">BU Professor Ed Damiano and Dr. Betsey Monaco in conversation.<\/h2><div class=\"bu_collapsible_section\" style=\"display: none;\"><br \/>\n<div class=\"vertical-video\"><\/p>\n<div class=\"responsive-video responsive-youtube\"><iframe loading=\"lazy\" title=\"The Impact of the iLet Bionic Pancreas, Created by a BU Professor | You Are Why\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/2DoEkDFa5ig?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<p><\/div><br \/>\n<\/div>\n<\/div>\n<\/p><\/div>\n<p><strong>ED DAMIANO: You and your husband had been responsible for every dose of insulin your son received. And you put him on a device that is autonomously responsible for the doses he would receive?<\/strong><\/p>\n<p><strong>BETSEY MONACO:<\/strong> It was definitely\u2014especially for me, as a physician\u2014a total release of control. And it was terrifying and amazing\u2014all in the same moment. We really wanted something that was going to give him the life that other kids have, to just be able to turn it on and let it do its thing.<\/p>\n<p><strong>Many people struggle with that, at least in the first few weeks\u2014with giving up that kind of control, which, until the iLet became available, was essential to the well-being of your child.<\/strong><\/p>\n<p>The first time, it was hard for me and it was scary, but we found that it worked, and it didn\u2019t take more than a couple of days for us to get comfortable with the idea that there\u2019s tech out there that can do this\u2014these guys have figured it out, and here we are. It\u2019s hard to leave kids with diabetes, and so it was hard at the beginning with the iLet, too. But we all pretty quickly got pretty comfortable because it just worked.<\/p>\n\n<div class=\"bu-stat-list bu-stat-count-2 \">\n\n\t\n\t\t\n<article class=\"bu-stat-single js-bu-stat-single bu-stat-has-description bu-stat-type-number bu-stat-theme-default bu-stat-has-max-characters-1 post-298 bu_stat type-bu_stat status-publish hentry\" >\n\t<div class=\"bu-stat-inner js-bu-stat-inner\">\n\t\t\n\t\t\n\t\t<div class=\"bu-stat-element\">\n\n\t\t\t<div class=\"bu-stat-value-container bu-stat-value-one  bu-stat-has-suffix bu-stat-has-suffix-M\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"bu-stat-value\">\n\t\t\t\t\t<span class=\"bu-stat-value-field\">2<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"bu-stat-suffix bu-stat-suffix-M\">\n\t\t\t\t\t\t<span class=\"bu-stat-value-field\">M<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div><!-- \/.bu-stat-value-container -->\n\n\t\t<\/div><!-- \/.bu-stat-element -->\n\n\t\t\t\t\t<p class=\"bu-stat-description\">\n\t\t\t\tPeople in the US of all ages with type 1 diabetes\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n<\/article>\n\n\t\n\t\t\n<article class=\"bu-stat-single js-bu-stat-single bu-stat-has-description bu-stat-type-number bu-stat-theme-default bu-stat-has-max-characters-2 post-300 bu_stat type-bu_stat status-publish hentry\" >\n\t<div class=\"bu-stat-inner js-bu-stat-inner\">\n\t\t\n\t\t\n\t\t<div class=\"bu-stat-element\">\n\n\t\t\t<div class=\"bu-stat-value-container bu-stat-value-one  bu-stat-has-suffix bu-stat-has-suffix-K\">\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"bu-stat-value\">\n\t\t\t\t\t<span class=\"bu-stat-value-field\">25<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"bu-stat-suffix bu-stat-suffix-K\">\n\t\t\t\t\t\t<span class=\"bu-stat-value-field\">K<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div><!-- \/.bu-stat-value-container -->\n\n\t\t<\/div><!-- \/.bu-stat-element -->\n\n\t\t\t\t\t<p class=\"bu-stat-description\">\n\t\t\t\tiLet users in its first two years on the market\t\t\t<\/p>\n\t\t\t\t\t<\/div>\n<\/article>\n\n\t\n<\/div>\n\n<p><strong>What was it like when both of your boys were diagnosed with type 1 diabetes?<\/strong><\/p>\n<p>It was certainly new and totally life-changing for our family. Frankie, Rory\u2019s older brother, got diabetes when he was four, and life got a lot harder in terms of taking care of him and just letting him do things that kids need to do in school and sports and after-school activities. And when Rory was diagnosed a few years later, it was the same thing.<\/p>\n<figure id=\"attachment_180\" aria-describedby=\"caption-attachment-180\" style=\"width: 646px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" src=\"\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-636x424.jpg\" alt=\"\" width=\"636\" height=\"424\" class=\"size-medium wp-image-180\" srcset=\"https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-636x424.jpg 636w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-1024x683.jpg 1024w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-768x512.jpg 768w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-1536x1024.jpg 1536w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-539-2-2-2048x1365.jpg 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><figcaption id=\"caption-attachment-180\" class=\"wp-caption-text\">Rory, along with his parents, found that life was easier with the iLet. He could play like a kid and eat like a kid. And his parents didn\u2019t have the added worry of constantly monitoring his blood sugar levels.<\/figcaption><\/figure>\n<p><strong>I remember once you made a comment that even as a physician, you\u2019re scared to give too much insulin. Is that right?<\/strong><\/p>\n<p>My husband\u2019s an engineer and I\u2019m a physician, so between us, the physiology and the math, we\u2019re both really good at those things. There\u2019s a lot of both of those in managing type 1. And I don\u2019t know how people without that background do it because it\u2019s definitely tricky.<\/p>\n<p><strong>How did it feel, as a parent, to live with this chronic illness?<\/strong><\/p>\n<p>Even though I was a physician and understood it all pretty well, I didn\u2019t understand what it would feel like to leave them at a friend\u2019s house or send them to school or any of those things. I remember talking about it with Paul, how we were just never going to sleep again. Correcting blood sugar, especially overnight, is hard. It\u2019s not an easy way of life.<\/p>\n<p><strong>Frankie experienced the iLet in a large, clinical Boston University\u2013funded study. He was possibly the youngest person in the trial at six years old.<\/strong><\/p>\n<p>We had an endocrinologist who\u2019s a colleague of mine, and when the iLet started clinical trials, she said, \u201cDo you want me to connect you?\u201d And I said, \u201cAbsolutely.\u201d Frankie was only six, so I said [to him], \u201cDo you want to do this? Because you\u2019re going to have to get your blood drawn and I don\u2019t know what this device is going to do.\u201d And he said, \u201cIf this might be better than what I\u2019m doing now, sign me up.\u201d<\/p>\n<p><strong>How do the boys feel about the iLet?<\/strong><\/p>\n<p>The iLet makes them feel more like typical kids. They don\u2019t have to worry about what they\u2019re eating and how much of it or about doing the things they\u2019re used to doing with their friends.<\/p>\n<blockquote><p>\u201cThe iLet makes them feel more like typical kids.\u201d<br \/>\n\u2014Betsey Monaco<\/p><\/blockquote>\n<p><strong>Frankie\u2019s trial ended at 13 weeks and you had to turn the device over. What was that like?<\/strong><\/p>\n<p>I literally cried the day we had to give it back. That was a huge backward step for us. His hemoglobin A1C\u2014an indicator that gives a sense of average blood sugar levels over a period of time and, thus, how well those levels are being controlled\u2014is a marker we follow in kids with diabetes. Frankie\u2019s was the lowest it\u2019s ever been. Rory\u2019s A1C has also come down. This device helps to keep their blood sugar within target ranges all the time.<\/p>\n<p><img loading=\"lazy\" src=\"\/2025\/files\/2025\/11\/25-1419-AR2-387-2-636x424.jpg\" alt=\"Two young boys kicking a ball in an empty field with their parents\" class=\"alignnone wp-image-536 size-medium\" width=\"636\" height=\"424\" srcset=\"https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-387-2-636x424.jpg 636w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-387-2-1024x683.jpg 1024w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-387-2-768x512.jpg 768w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-387-2-1536x1024.jpg 1536w, https:\/\/ar.bu.edu\/2025\/files\/2025\/11\/25-1419-AR2-387-2-2048x1365.jpg 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n<figure id=\"attachment_87\" aria-describedby=\"caption-attachment-87\" style=\"width: 244px\" class=\"wp-caption alignright\"><img loading=\"lazy\" src=\"\/2025\/files\/2025\/11\/bionic-pancreas-485x636_CydneyScott.jpg\" alt=\"An image of the iLet bionic pancreas device being held in a hand\" width=\"234\" height=\"307\" class=\" wp-image-87\" \/><figcaption id=\"caption-attachment-87\" class=\"wp-caption-text\">About the size of a deck of cards, the iLet Bionic Pancreas autonomously delivers insulin to help stabilize the user\u2019s blood sugar levels.<\/figcaption><\/figure>\n<p><strong>The trial ended at the end of 2021 and the iLet didn\u2019t come to market until the middle of 2023\u2026<\/strong><\/p>\n<p>In that year and a half, Rory was diagnosed and started on injection therapy. He also went on a different pump briefly. As soon as the iLet became commercially available, I was asking for it. Rory was [our hospital\u2019s] first pediatric patient to get it. Frankie wants to switch back to the iLet. So I think we will do that.<\/p>\n<p><strong>What are the implications for the broader population?<\/strong><\/p>\n<p>The nice thing about the iLet is that anyone can do this right. For the diabetes community, to have a device that makes life as close to normal as possible is huge.<\/p>\n<p><strong>Is it going to change the boys\u2019 lives?<\/strong><\/p>\n<p>I think so. I hope so. One thing I\u2019ve seen as a physician is the health complications diabetes presents later in life. A lifetime of high blood sugar can do a lot of things to your body. And these kids are the first to have the benefit of such good control from day one. They will be healthier in the long run, and it allows them to live a more normal life. I\u2019ll always be keeping an eye on them, but the device definitely makes it easier for them to live their lives.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Above: Rory Mansfield has type 1 diabetes but lives a normal life, says his mother, Betsey Monaco, a pediatrician. Ed Damiano, research professor of biomedical engineering at Boston University, coinvented the iLet Bionic Pancreas, an automated insulin delivery device. Rory Mansfield has type 1 diabetes, but these days he can visit a friend\u2019s house, play [&hellip;]<\/p>\n","protected":false},"author":16543,"featured_media":0,"parent":68,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/pages\/78"}],"collection":[{"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/users\/16543"}],"replies":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/comments?post=78"}],"version-history":[{"count":50,"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/pages\/78\/revisions"}],"predecessor-version":[{"id":654,"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/pages\/78\/revisions\/654"}],"up":[{"embeddable":true,"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/pages\/68"}],"wp:attachment":[{"href":"https:\/\/ar.bu.edu\/2025\/wp-json\/wp\/v2\/media?parent=78"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}